Lawsuits, corporate investigations, and regulatory audits are increasing in number -- rapidly. In 2008, 34% of corporations noted that they are expecting a significant increase in litigation as a result of the financial crisis. The amount of electronically stored information is also increasing. More than 90% of new business records are created electronically, and 40% of them are never converted to paper. The net result: companies are struggling to control skyrocketing e-discovery costs and to complete investigations with existing resources. This paper details several best practices derived from real-world cases and explains how Clearwell customers have met their e-discovery challenges and achieved a significant return on investment (ROI) -- often within a single case.